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Metronidazole has demonstrated proof of mutagenic activity in a number of in vitro bacterial assay programs. Furthermore, a dose-similar rise in the frequency of micronuclei was noticed in mice just after jnetoto intraperitoneal injections. A rise in chromosomal aberrations in peripheral blood lymphocytes was noted in individuals with Crohn’s ailment who had been handled with 200 to 1200 mg/day of metronidazole for one to 24 months.

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Even so, no excess chromosomal aberrations in circulating human lymphocytes are observed in people taken care of for eight months.

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